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HPE ProLiant Gen12 rack and tower servers

A secure foundation to power new workloads while streamlining operations and cutting energy use. Gen12 spans Intel® Xeon® 6 rack and tower systems, NVIDIA accelerated platforms, and the NVIDIA® Vera CPU–based DL394 for agentic AI — all wrapped in the security, manageability, and lifecycle tooling enterprises trust from HPE ProLiant.

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HPE ProLiant Compute Gen12 server family
Up to 65%
Power savings per year vs. legacy systems
Up to 41%
Better performance per watt
iLO 7
FIPS 140-3 Level 3, quantum-resistant ready
7:1
One Gen12 server replaces seven Gen10 servers
Why Gen12

Next-generation ProLiant, engineered for what comes next

HPE ProLiant Compute Gen12 meets federal security certification standards, boosts IT productivity with AI-driven insights, and drives major power savings — right-sized for AI, data analytics, edge, hybrid cloud, and VDI.

Next-level security

HPE iLO 7 adds a dedicated secure-enclave security processor — the first server with quantum computing-resistant readiness and FIPS 140-3 Level 3 cryptographic certification.

Performance and efficiency

Up to 41% better performance per watt and up to 65% power savings per year, with optional direct liquid cooling on Intel-based one- and two-socket rack servers.

AI-driven productivity

HPE Compute Ops Management secures and automates server environments with AI-informed insights, map-based visibility, and third-party tool integration.

The Lineup

HPE ProLiant DL Gen12 servers

Rack-dense compute from 1U single-socket to 4U accelerated platforms, plus the Vera CPU–based DL394 built for agentic AI. Pick a model below, compare the full Gen12 lineup, or have us spec it for you.

DL394 Gen12

2U server powered by the NVIDIA® Vera CPU — built for agentic AI and reinforcement learning, with 88 Olympus cores and up to 1.2 TB/s memory bandwidth. Explore the DL394

DL110 Gen12

Short-depth, NEBS Level 3-ruggedized 1U single-socket telco/edge server with Intel® Xeon® 6 SoC processors with Intel vRAN Boost, 8x25GbE onboard, and optional GNSS precision timing for vRAN and 5G edge. Explore the DL110

DL320 Gen12

1U single-socket rackmount that maximizes rack utilization while mitigating virtualization risks in power-constrained environments. View models

DL325 Gen12

1U single-socket server with 5th Gen AMD EPYC processors up to 192 cores and up to 6 TB DDR5 — built to maximize rack utilization in power-constrained environments. View the DL325

DL340 Gen12

2U single-socket server with reduced power draw and better thermals for data- and storage-centric workloads that need more PCIe lanes. View models

DL345 Gen12

Scalable 2U single-socket server with 5th Gen AMD EPYC processors up to 192 cores and up to 36 EDSFF drives — exceptional compute and large-capacity storage at 1P economics. View the DL345

DL360 Gen12

Compact 1U 2P server delivering exceptional compute performance, memory density, scalability, and high-speed data transfer for demanding applications. View models

DL380 Gen12

Two-socket scalable server that powers data analytics and supports hybrid cloud workloads. View models

DL380a Gen12

4U 2P accelerator-optimized platform with 6th Gen Intel® Xeon® CPUs up to 144 cores, up to 8 TB DDR5, and up to 8 double-wide GPUs for AI inferencing at scale. Explore the DL380a

DL384 Gen12

2U platform with up to two NVIDIA GH200 Grace Hopper Superchips — large coherent memory and integrated Hopper GPUs for large-language-model AI inferencing. Explore the DL384

DL580 Gen12

4U up-to-4-socket server with Intel Xeon 6 processors and up to 16 TB DDR5 — engineered for mission-critical database, analytics, virtualization, and in-memory workloads such as SAP HANA. Explore the DL580

The Lineup

HPE ProLiant ML Gen12 servers

Tower form factors for offices and edge sites that need datacenter-class capability without a datacenter.

ML350 Gen12

Robust 2P tower server with an optional rackable chassis, delivering exceptional compute performance, security, reliability, and expandability for varied environments. View models

What's Inside Gen12

Security, efficiency, and AI operations as standard

Every Gen12 server inherits the same foundation, so the choice between models is about form factor and workload — not about giving up protection or manageability.

  • HPE iLO 7 secure enclaveDedicated HPE-designed security processor, quantum-resistant readiness, and FIPS 140-3 Level 3 certification.
  • Up to 41% better performance per wattRight-sized for AI, data analytics, edge, hybrid cloud, and VDI, with optional direct liquid cooling.
  • Up to 65% annual power savingsOne Gen12 server delivers the compute of seven Gen10 servers, freeing data center capacity.
  • HPE Compute Ops ManagementCloud-based, AI-informed insights, map-based visibility, and third-party tool integration for Gen10 and newer.
HPE ProLiant Compute Gen12 server family
Authorized HPE Partner

Eight Gen12 models, one right answer for your workload

Processor family, memory, storage, networking, GreenLake consumption, and lead times differ across the DL and ML lineup. Tell us what your workloads need to do, and we'll land you on the right Gen12 build, get you pricing that makes sense, and stay on the order until it's racked.

  • Configuration guidance from people who know the HPE ProLiant catalog
  • Authorized-partner pricing, without the usual procurement friction
  • Order follow-through — from quote to delivery
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Availability

When the Gen12 portfolio ships

Q1 2025

Six of the eight new Intel Xeon 6–based Gen12 servers ship first: DL320, DL340, DL360, DL380, DL380a, and ML350 Gen12.

Summer 2025

HPE Synergy 480 and HPE ProLiant Compute DL580 Gen12 servers are expected to follow.

Standalone or GreenLake

The full Gen12 portfolio is available as a standalone purchase or as a service via HPE GreenLake.

Resources

Datasheets & downloads

HPE ProLiant Compute Gen12 Servers
Portfolio overview: security, efficiency, and AI operations (PDF)
DL394 Gen12 Solution Brief
CPU-optimized powerhouse for the era of agentic AI (PDF)
FAQ

HPE ProLiant Gen12 servers: common questions

HPE ProLiant Compute Gen12 is HPE's next-generation server portfolio spanning Intel Xeon 6 rack and tower systems, NVIDIA accelerated platforms, and the NVIDIA Vera CPU–based DL394, engineered for AI, data analytics, edge, hybrid cloud, and VDI.

HPE cites up to 65% power savings per year and up to 41% better performance per watt versus legacy systems, with one Gen12 server delivering the compute of seven Gen10 servers.

HPE iLO 7 adds a dedicated secure-enclave security processor with FIPS 140-3 Level 3 cryptographic certification and quantum computing-resistant readiness.

The lineup includes DL320, DL340, DL360, DL380, DL380a, DL384, DL394, and ML350 Gen12. Six Intel Xeon 6-based models (DL320, DL340, DL360, DL380, DL380a, and ML350) shipped first in Q1 2025.

Yes. The full Gen12 portfolio is available as a standalone purchase or as a service via HPE GreenLake.

Get Started

Build your Gen12 server today

Tell us about your workloads and a ServerComputeWorks specialist will help you choose, configure, price, and order the right HPE ProLiant Gen12 system.

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*Intel and Xeon are trademarks of Intel Corporation. NVIDIA, Vera, Grace, and Hopper are trademarks and/or registered trademarks of NVIDIA Corporation. SPEC and SPECrate are registered trademarks of the Standard Performance Evaluation Corporation. FIPS 140-3 Level 3 certification is a standard adopted by NIST and CNSA 2.0. Performance and power-savings claims are based on internal HPE measurements and SPECrate2017_int_base results published on spec.org. All other third-party trademark(s) is/are property of their respective owner(s). Specifications and availability are subject to change.