HPE ProLiant DL385 Gen11 9354 Server
32‑core 3.25GHz, 384GB RAM
Sorry, this product is no longer available, please contact us for a replacement.
Find the Right Services & Add-Ons
Jump to the pricing table to view available options. If you don’t find exactly what you need, our team will guide you and tailor a solution.
Overview:
Are you looking for an accelerator-optimized performance solution to run your AI or Big Data analytics workloads?
The HPE ProLiant DL385 Gen11 server is a 2U 2P solution that delivers exceptional compute performance, upgraded high-speed data transfer rate and memory depth at 2P compute capability. Powered by 4th & 5th Generation AMD EPYC™ 9004 & 9005 Series Processors with up to 160 cores, increased memory bandwidth and capacity, high-speed PCIe Gen5 I/O, enhanced GPU support, and EDSFF storage, the HPE ProLiant DL385 Gen11 server is a superb accelerator-optimized 2U 2P solution.
Enhanced security features with the silicon root of trust from HPE are built into the firmware, creating a digital fingerprint for the AMD Secure Processor to validate safe operation prior to boot.
HPE ProLiant DL385 Gen11 server is an excellent choice for compute and data storage demanding workloads requiring increased core count, and storage and I/O scalability.
What's New
- Powered by the 4th & 5th Generation AMD EPYC™ 9004 & 9005 Series Processors with 5nm technology that supports up to 160 cores at 400W, 1152 MB L3 Cache, and 24 DIMMs for DDR5 memory up to 6000 MT/s.
- 12 DIMM channels per processor for up to 6 TB total DDR5 memory with increased memory bandwidth and performance, and lower power requirements.
- Advanced data transfer rates and higher network speeds from the PCIe Gen5 serial expansion bus, with up to 2x16 PCIe Gen5 and two OCP slots.
- Includes HPE Integrated Lights-Out 6 (iLO 6) server management software that enables you to securely configure, monitor, and update your HPE ProLiant Gen11 servers seamlessly from anywhere.
- Supports hot-pluggable, high-availability RAID M.2 boot options.
- PCIe Gen5 EDSFF support and up to 8x single-wide and 4x double-wide GPU support.
Features:
Intuitive Cloud Operating Experience: Simple, Self-service, and Automated
HPE ProLiant DL385 Gen11 servers are engineered for your hybrid world. The HPE ProLiant Gen11 servers simplify the way you control your business’s compute—from edge to cloud—with a cloud operating experience.
Transform business operations and pivot your team from reactive to proactive with global visibility and insight through a self-service console.
Automate tasks for efficiency in deployment and instant scalability for seamless, simplified support and lifecycle management, reducing tasks and shortening maintenance windows.
These experiences are engineered and built into all HPE ProLiant Gen11 servers, whether purchased as physical servers or consumed as-a-service using HPE GreenLake as your compute and storage demands grow.
Simplify and secure server management from edge to cloud with HPE GreenLake for Compute Ops Management HPE GreenLake for Compute Ops Management is an as-a-service compute management experience that delivers greater simplicity, agility, and speed across your entire compute landscape, globally.
Trusted Security by Design: Uncompromising, Fundamental, and Protected
The HPE ProLiant DL385 Gen11 server is tied into the silicon root of trust and the AMD Secure Processor, a dedicated security processor embedded in the AMD EPYC system on a chip (SoC), to manage secure boot, memory encryption, and secure virtualization.
HPE ProLiant Gen11 servers use the silicon root of trust to anchor the firmware of an HPE ASIC, creating an immutable fingerprint for the AMD Secure Processor that must be matched exactly before the server will boot. This helps ensure malicious code is contained, and healthy servers are protected.
HPE ProLiant Gen11 servers continuously protect healthy servers at the edge by providing rapid detection of security-compromised servers, even to the point of not allowing them to boot if it identifies and contains malicious code, with IDevID certificates installed by default.
HPE ProLiant Gen 11 servers provide automated recovery from a security event, including restoration of validated firmware, and facilitating recovery of the operating system, application, and data connections, and providing a fast path to bring a server back online and into normal operations.
From silicon to software, from factory to cloud, and from generation to generation, HPE ProLiant Gen11 is engineered with a fundamental security approach to defend against increasingly complex threats through an uncompromising commitment to constant security advancements that are built into our DNA.
Customized Performance for your Workloads: Accelerated, Open, and Efficient
Harness major computer performance. The HPE ProLiant DL385 Gen11 server is powered by the 4th & 5th Generation AMD EPYC™ 9004 & 9005 Series Processors with 5nm technology that supports up to 160 cores, 400W, and 1152 MB of L3 cache.
Advanced data transfer rates and higher network speeds from the PCIe Gen5 serial expansion bus, with up to 8x16 PCIe Gen5 and two OCP slots, improve I/O throughput and reduce latency.
Increased memory bandwidth and performance, and lower power requirements with 12 DIMM channels per processor for up to 6 TB total DDR5 memory.
Provide real-time operational feedback on server performance plus recommendations for fine-tuning BIOS settings to customize for changing business needs.
Technical Specifications:
| HPE ProLiant DL385 Gen11 9354 3.25GHz 32c 2P 384GB-R 8SFF NS204i-u NC BCM57414 2x1000W PS NA Server Specifications | |
|---|---|
| Detailed product description | HPE ProLiant DL385 Gen11 server with two AMD EPYC™ 9354 Processors, one Optional, 384 GB (24x16 GB) Single Rank Memory, one HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device, Drive Bay(s) for 8 small form factor drives, six HPE ProLiant DL3X5 Gen11 2U Performance Fan Kits, two HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kits, and a 3/3/3 warranty |
| Product Number | P77251-005 |
| Processor name | AMD EPYC™ 9354 (32 core, 3.25 GHz, 256 MB L3, 280W) |
| Processor number | 2 processor included |
| Processor core available | 32 core, per processor |
| Processor cache | 256 MB L3 |
| Processor speed | 3.25 GHz |
| Power supply type | 2x HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit |
| Expansion slots | 8 maximum, for detailed descriptions refer to the QuickSpecs |
| Memory type | HPE DDR5 Smart Memory |
| Included Memory | 384 GB (24x16 GB, 4800 MT/s) |
| Included drives | None ship standard, 8 SFF supported |
| System fan features | 6x Performance fans |
| Network controller | 1x Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE 1x Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE |
| Storage controller | HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device |
| Infrastructure management | HPE iLO Standard with Intelligent Provisioning (embedded), HPE OneView Standard (requires download); HPE iLO Advanced, HPE iLO Advanced Premium Security Edition, and HPE OneView Advanced (require licenses) Compute Ops Management Software |
| Warranty | 3/3/3: Server Warranty includes three years of parts, three years of labor, and three years of onsite support coverage. |
Hardware Specs:
HPE ProLiant DL385 Gen11 server
HPE ProLiant DL385 Gen11 SFF Server- Front View
| 1 | Quick removal access panel |
| 2 | Power On/Standby button and system power LED button |
| 3 | Health LED |
| 4 | iLO front service port |
| 5 | NIC status LED |
| 6 | USB 3.2 Gen1 |
| 7 | UID button |
| 8 | Drive Bay 3. 8 SFF U.3 optional |
| 9 | Drive Bay 2. 8 SFF U.3 optional |
| 10 | Drive Bay 1. 8 SFF U.3 or Universal Media Bay optional |
| 11 | Serial label pull tag |
HPE ProLiant DL385 Gen11 - Rear View
| 1 | Primary Riser: PCI Slots (Slots 1–3 top to bottom) |
| 2 | OCP 3.0 Slot |
| 3 | Secondary Riser: PCI Slots (Slots 4–6 top to bottom) |
| 4 | Tertiary Riser: (Slots 7–8 top to bottom, not shown). Optional rear 2 SFF cage |
| 5 | Hot pluggable M.2 Boot Device (optional, not shown) |
| 6 | HPE Flexible Slot power supply bay 1 |
| 7 | HPE Flexible Slot Power Supply bay 2 |
| 8 | VGA connector |
| 9 | Serial port (optional) |
| 10 | Dedicated iLO management port |
| 11 | USB 3.2 Gen1 ports |
HPE ProLiant DL385 Gen11 - Internal View
| 1 | DDR5 DIMM slots. Shown populated in 24 slots |
| 2 | Hot Pluggable M.2 Boot Device bracket |
| 3 | (Under) Up to 2 Hot Plug redundant HPE Flexible Slot Power supplies |
| 4 | Rear 2SFF drive cage |
| 5 | Secondary PCIe riser cage |
| 6 | (Under) OCP 3.0 Slot 2 |
| 7 | Primary PCIe riser cage |
| 8 | (Under) OCP 3.0 Slot 1 |
| 9 | 2x USB 3.2 Gen1 ports (one under primary riser cage) |
| 10 | Fan cage shown with 6 Performance Hot-plug fans |
| 11 | 2 Processors (heatsinks shown) |
Services & Add-Ons:
HPE Tech Care (Support Plans)
HPE Tech Care is an operational support service from HPE for hardware, software, and multivendor systems. It helps your systems run smoothly, improves reliability, and drives performance. Official HPE Tech Care Datasheet
- Hardware & software support from HPE experts
- Access via phone, email, chat & self-service tools
- Standard response times & on-site as per HPE availability
- General technical guidance for operations & management
- All features in Basic, plus faster response & support
- Enhanced phone response; quicker callback for severity-1 incidents
- Proactive technical guidance and more frequent advisory from HPE
- Self-serve tools and knowledge base + access to digital insights via HPE
| Feature | Basic | Essential |
|---|---|---|
| Hardware & Software Coverage | HPE-provided support for both hardware & software | Same, with faster response & enhanced assistance |
| Support Channels | Phone, email, chat, self-service tools | All channels + more aggressive response SLAs |
| Response Time | Standard response per HPE’s availability | Improved/faster response for high-severity issues (e.g. severity-1) |
| Proactive Guidance | General technical guidance | Extra guidance in usage, management, and performance opportunities |
HPE iLO Advanced (Remote Management)
HPE Integrated Lights-Out (iLO) Advanced unlocks secure, full-feature remote administration for HPE ProLiant servers—enabling setup, monitoring, troubleshooting, and power control from anywhere.
Key Capabilities
- Integrated Remote Console with virtual keyboard and mouse
- Virtual media & folders for remote OS/software installs
- Console record & playback for audit and troubleshooting
- Collaborative access for multiple administrators
- Power/thermal monitoring with history and dynamic capping
- iLO Federation group management (group media, power, licensing)
Security & Compliance
- Silicon Root of Trust and platform component integrity checks
- Directory integration and 2-factor authentication (CAC/PIV)
- Device identity (IDevID/LDevID) aligned with IEEE 802.1AR
- Kerberos-based single sign-on for streamlined access
| Feature | iLO Standard | iLO Advanced |
|---|---|---|
| Remote Console | Basic access | Full Integrated Remote Console with collaboration |
| Virtual Media | Limited | Virtual media & folders for remote installs |
| Recording | — | Console record & playback |
| Power & Thermal | Monitoring | Monitoring + history and dynamic power capping |
| Federation (Group Mgmt) | Limited | Group media, power control, power capping, license activation |
| Security | Baseline iLO security | Directory auth, CAC/PIV, Kerberos, device identities, silicon root of trust enhancements |
Microsoft Windows Server 2025 (ROK AMS Software)
Choose the right edition of Microsoft Windows Server 2025 to power your Smart Choice Servers and Storage. Each edition is tailored to different business sizes and virtualization needs.
Essentials10-Core
- Up to 25 users / 50 devices
- Simplified licensing for small businesses
- No virtualization rights
Standard16-Core
- For growing businesses
- Supports 2 virtual machines
- Full Windows Server feature set
Datacenter16-Core
- For enterprises & data centers
- Unlimited virtualization rights
- Advanced features for large-scale workloads
| Edition | Best For | Virtualization | Users / Devices |
|---|---|---|---|
| Essentials | Small businesses | None | 25 users / 50 devices |
| Standard | SMBs with moderate workloads | Up to 2 VMs | Licensed per 16-core base + CALs |
| Datacenter | Enterprises / virtualization-heavy environments | Unlimited VMs | Licensed per 16-core base + CALs |
HPE Storage Options
Choose the right storage for your Smart Choice Servers. HPE offers HDD, SSD, and SAS options, each with different balances of cost, performance, and reliability.
HDD Hard Disk Drive
- Large capacity, lower cost
- Slower performance
- Great for bulk storage & backups
SSD Solid-State Drive
- High performance, faster boot & apps
- Better for databases & OS
- Higher cost per GB
SAS Serial Attached SCSI
- Enterprise-grade reliability
- High performance for mission-critical workloads
- Designed for 24/7 operations
| Type | Best For | Performance | Cost |
|---|---|---|---|
| HDD | Bulk storage, backups | Slowest | Low |
| SSD | OS, applications, databases | High | Medium–High |
| SAS | Enterprise workloads, 24/7 uptime | Very High | High |
HPE Memory Options
Smart Choice Servers and Storage support DDR5 memory for improved performance, efficiency, and scalability. Choosing the right amount of memory ensures your workloads run smoothly, whether it’s databases, virtualization, or everyday applications.
16GB DDR5-4800
- Good for basic workloads & file servers
- Suitable for small office environments
- Entry-level performance
32GB DDR5-4800
- Ideal for virtualization, databases, and multitasking
- Supports more demanding business workloads
- Higher performance headroom
| Option | Best For | Performance | Scalability |
|---|---|---|---|
| 16GB DDR5-4800 | Entry workloads, file/print servers | Baseline | Limited |
| 32GB DDR5-4800 | Virtualization, databases, larger workloads | High | Better scalability with more DIMMs |
Quick Recommendations
To help you decide, we’ve put together sample configurations that match common business needs.
Small Office / Basic Workloads
- Support: Tech Care Basic (3Y)
- Remote Mgmt: Optional iLO Advanced
- OS: Windows Server 2025 Essentials
- Storage: HDD (affordable, large capacity)
- Memory: 16GB DDR5
Why: Essentials edition is perfect for ≤25 users, while 16GB RAM and HDDs keep costs low. iLO Advanced is optional if you don’t need remote management.
Growing Business / Virtualization
- Support: Tech Care Essential (5Y)
- Remote Mgmt: iLO Advanced (3Y)
- OS: Windows Server 2025 Standard
- Storage: SSD (OS/apps) + HDD (data)
- Memory: 32GB DDR5
Why: Standard edition allows up to 2 VMs for growth. A mix of SSD + HDD balances performance and cost. iLO Advanced ensures remote management as IT expands.
Enterprise / Mission-Critical Workloads
- Support: Tech Care Essential (5Y)
- Remote Mgmt: iLO Advanced with Federation
- OS: Windows Server 2025 Datacenter
- Storage: SAS drives (high reliability)
- Memory: 32GB+ DDR5 (expandable)
Why: Datacenter edition unlocks unlimited virtualization. SAS drives support 24/7 uptime, while more RAM ensures smooth performance across many workloads.
Branch Office / Remote Site
- Support: Tech Care Essential (3Y)
- Remote Mgmt: iLO Advanced (critical for remote access)
- OS: Windows Server 2025 Standard
- Storage: SSD for fast apps, small HDD for data
- Memory: 16GB or 32GB DDR5
Why: Remote management via iLO is vital since IT staff may not be on-site. Standard edition supports light virtualization or file/print roles for branch users.
Development / Test Lab
- Support: Tech Care Basic (1–3Y)
- Remote Mgmt: iLO Advanced (collaboration features)
- OS: Windows Server 2025 Standard
- Storage: SSD-heavy (fast rebuilds)
- Memory: 32GB DDR5
Why: Developers benefit from iLO’s remote console recording/playback and SSD speed for frequent rebuilds. Standard edition licensing suits multiple test VMs.
Documentation:
Download the HPE ProLiant DL385 Gen11 9354 3.25GHz 32c 2P 384GB-R 8SFF NS204i-u NC BCM57414 2x1000W PS NA Server Data sheet (.PDF)
Download the HPE ProLiant DL385 Gen11 server Datasheet (.PDF)
Download the HPE ProLiant DL385 Gen11 server Quick Specs (.PDF)
*AMD EPYC™ is a trademark of Advanced Micro Devices, Inc. All third-party marks are property of their respective owners.
Pricing Notes:
- Pricing and product availability subject to change without notice.
List Price:
Our Price: $792.30
List Price:
Our Price: $1,470.60
List Price:
Our Price: $1,145.70
List Price:
Our Price: $2,057.70
List Price:
Our Price: $445.55
List Price:
Our Price: $379.05
List Price:
Our Price: $445.55
List Price:
Our Price: $379.05
List Price:
Our Price: $1,089.65
List Price:
Our Price: $5,426.40
List Price:
Our Price: $422.75